Dtl - denticleless E3 ubiquitin protein ligase

Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to act upstream of or within DNA replication and rhythmic process. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; genitourinary system; hemolymphoid system gland; lung; and medulla oblongata part of 4th ventricle choroid plexus. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Apr 2022]