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中文人类
ZAP70 - Zeta Chain Of T Cell Receptor Associated Protein Kinase 70
Alias:
SRK
STD
TZK
STCD
IMD48
ADMIO2
ZAP-70
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这个基因编码一种属于酪氨酸蛋白激酶家族的酶，它在T细胞发育和淋巴细胞激活中发挥作用。这个酶在受到T细胞抗原受体（TCR）刺激后，其酪氨酸残基被磷酸化，与Src家族激酶Lck和Fyn一起，在TCR介导的信号传导的初始步骤中发挥作用。这个酶对胸腺细胞的发育也是必不可少的。这个基因的突变导致选择性T细胞缺陷，这是一种严重的联合免疫缺陷病，其特点是选择性缺乏CD8阳性T细胞。已经发现这个基因有两种编码不同异构体的转录变异体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ZAP70 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
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Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
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PMID
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