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中文人类
YWHAE - Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Alias:
MDS
HEL2
MDCR
KCIP-1
14-3-3E
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这个基因产物属于14-3-3家族蛋白质，通过结合含磷酸丝氨酸的蛋白质来调节信号传导。这个高度保守的蛋白质家族在植物和哺乳动物中都有发现，这个蛋白质与小鼠的直向同源蛋白质有100%的相同性。它与CDC25磷酸酶、RAF1和IRS1蛋白质相互作用，提示它在与信号传导相关的多种生物化学活动中发挥作用，如细胞分裂和胰岛素敏感性的调节。它还被认为与小细胞肺癌的病理发生有关。已发现这个基因有两个转录变异体，一个是蛋白质编码变异体，另一个是非蛋白质编码变异体。[由RefSeq，2008年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
YWHAE Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
