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中文人类
XRCC5 - X-ray Repair Cross Complementing 5
Alias:
KU80
KUB2
Ku86
NFIV
KARP1
KARP-1
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这个基因编码的蛋白质是Ku异源二聚体蛋白质的80千道尔顿亚基，也称为ATP依赖的DNA解旋酶II或DNA修复蛋白XRCC5。Ku是DNA依赖的蛋白激酶的DNA结合成分，与DNA连接酶IV-XRCC4复合物一起作用，通过非同源末端连接修复DNA双链断裂，并完成V(D)J重组事件。这个基因功能互补中国仓鼠xrs-6，这是一种在DNA双链断裂修复和V(D)J重组能力方面有缺陷的突变体。这个基因中的罕见微卫星多态性与不同放射敏感性的患者癌症相关。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
XRCC5 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
