Log In|Sign Up
中文人类
NELFA - Negative Elongation Factor Complex Member A
Alias:
WHSC2
NELF-A
P/OKcl.15
Favorite
这种基因在胎儿组织中的表达水平高于成人组织。它编码一个与小鼠蛋白质有93%序列同一性的蛋白质。Wolf-Hirschhorn综合征（WHS）是一种与4号染色体短臂远端的半合删除有关的畸形综合征。该基因被映射到165kb的WHS关键区域，可能参与WHS或Pitt-Rogers-Danks综合征的表型。发现的编码蛋白质能够与HLA-A2限制性反应并具有肿瘤特异性的细胞毒性T淋巴细胞，这表明在大量癌症患者的特异性免疫治疗中可以作为靶点。该蛋白质已被证明是参与RNA聚合酶II转录延长调节的NELF（负向延长因子）蛋白质复合体的成员。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NELFA Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
