小鼠

Mlkl - mixed lineage kinase domain-like

Alias:
9130019I15Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因属于蛋白激酶超家族。编码的蛋白质包含一个蛋白激酶样结构域;然而,被认为缺乏蛋白激酶活性。这个蛋白质在肿瘤坏死因子(TNF)诱导的坏死中扮演关键角色,这是一种程序性细胞死亡过程,通过与受体相互作用蛋白3(Rip3)相互作用,Rip3是坏死途径中的关键信号分子。在小鼠中敲除这个基因显示它对坏死是必需的。已经发现了这个基因的可变剪接转录变异体。[由RefSeq,2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
6
11
27203 bp
54.32
28
13

Mlkl Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
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