人类

VRK1 - VRK Serine/threonine Kinase 1

Alias:
PCH1
PCH1A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个成员,该成员是痘苗相关激酶(VRK)家族的一员,该家族是丝氨酸/苏氨酸蛋白激酶。这个基因在人体组织中广泛表达,并在活跃分裂的细胞中表达增加,例如睾丸、胸腺、胎儿肝脏和癌细胞的那些。其蛋白质定位在核中,已被证明可以促进转录活性p53分子的稳定性和核积累,并在体外,对p53的Thr18进行磷酸化并减少p53的泛素化。因此,这个基因可能调节细胞增殖。这个蛋白质还磷酸化组蛋白、酪蛋白和转录因子ATF2(激活转录因子2)和c-JUN。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
10
13
84228 bp
45.48
427
5
7
20

VRK1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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