Sipa1l3 - signal-induced proliferation-associated 1 like 3

Predicted to enable GTPase activator activity. Involved in several processes, including epithelial cell morphogenesis; establishment of epithelial cell polarity; and eye development. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including nucleoplasm; stress fiber; and tricellular tight junction. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens vesicle. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Apr 2022]