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中文人类
VCP - Valosin Containing Protein
Alias:
p97
TERA
CDC48
FTDALS6
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这个基因编码一个属于AAA ATP酶家族的蛋白质成员。编码的蛋白质在蛋白质降解、细胞内膜融合、DNA修复和复制、细胞周期调节和NF-kappa B途径的激活中发挥作用。这个蛋白质形成一个六聚体复合物，与各种辅助因子相互作用，从脂质膜或蛋白质复合物中提取泛素化蛋白质。这个基因的突变导致IBMPFD（包含体肌病、骨Paget病和额颞部痴呆）、ALS（肌萎缩侧索硬化症）和人类患者的Charcot-Marie-Tooth病。[RefSeq,2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
VCP Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
