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中文小鼠
F13a1 - coagulation factor XIII, A1 subunit
Alias:
F13a
1200014I03Rik
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这个基因编码凝血因子XIII的A亚基，催化血液凝固途径的最后一步。编码的蛋白质与B亚基结合，形成异四聚前酶，然后经历thrombin介导的蛋白水解，生成活性因子XIIIa。因子XIIIa的转谷氨酰胺酶活性是纤维蛋白依赖钙的交联所必需的，从而导致血块的形成。缺乏编码的蛋白质的小鼠显示生殖受损和生存降低，因为它们容易发生出血、血胸、腹水和皮下出血。此外，缺乏编码的蛋白质的小鼠表现出伤口愈合受损和心肌梗死愈合不充分。可变剪接导致多个转录变异体。[RefSeq，2015年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
F13a1 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
