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中文人类
VAV1 - Vav Guanine Nucleotide Exchange Factor 1
Alias:
VAV
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这个基因是VAV基因家族的成员。VAV蛋白是Rho家族GTPases的鸟苷酸交换因子（GEFs），可激活导致肌动蛋白细胞骨架重新排列和转录改变的路径。编码的蛋白质在造血中发挥重要作用，参与T细胞和B细胞的发育和激活。已发现编码的蛋白质是HIV-1的Nef蛋白质的特定结合伙伴。这些伙伴的共同表达和结合启动显著的形态学变化、细胞骨架重新排列和JNK/SAPK信号级联，导致病毒转录和复制水平增加。已观察到这个基因的替代剪接转录变体编码多种异构体。[RefSeq，2012年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
VAV1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
