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中文人类
NR1H2 - Nuclear Receptor Subfamily 1 Group H Member 2
Alias:
NER
UNR
LXRB
LXR-b
NER-I
RIP15
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肝X受体LXRA（NR1H3；MIM 602423）和LXRB构成了核受体超家族的子家族，是巨噬细胞功能的关键调节者，控制与脂质稳态和炎症相关的转录程序。可诱导的LXRA在肝脏、肾上腺、肠道、脂肪组织、巨噬细胞、肺和肾脏中高度表达，而LXRB在全身各处广泛表达。配体激活的LXRs与类视黄醇X受体（RXRs；参见MIM 180245）形成必需异二聚体，并调节包含LXR响应元件的靶基因的表达（Korf等，2009年[PubMed 19436111]的概述）。[由OMIM于2010年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NR1H2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
