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中文人类
TYMS - Thymidylate Synthetase
Alias:
TS
TMS
DKCD
HST422
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胸苷酸合酶使用10-亚甲基四氢叶酸（亚甲基-THF）作为辅因子，催化脱氧尿苷酸甲基化为脱氧胸苷酸。这一功能维持了DNA复制和修复所必需的dTMP（胸苷-5'-单磷酸盐）池。该酶已成为癌症化疗药物的目标。被认为是5-氟尿嘧啶、5-氟-2'-脱氧尿苷和一些叶酸类似物的主要作用部位。此基因的表达和线粒体酶超家族成员1（基因ID：55556）这一天然反义转录物的表达在细胞生长从对数晚期进展到平台期时相反变化。此基因的多态性可能与包括乳腺癌在内的肿瘤发生的病因以及化疗反应有关。[RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TYMS Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
