Pot1b - protection of telomeres 1B

Enables single-stranded telomeric DNA binding activity and small GTPase binding activity. Acts upstream of or within several processes, including negative regulation of DNA recombination at telomere; protection from non-homologous end joining at telomere; and regulation of phagocytosis. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including genitourinary system; liver; lung; musculature; and spleen. Human ortholog(s) of this gene implicated in familial melanoma and high grade glioma. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2022]