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中文人类
TSC2 - TSC Complex Subunit 2
Alias:
LAM
TSC4
PPP1R160
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这个基因是一个肿瘤抑制基因，编码生长抑制蛋白tuberin。Tuberin与hamartin相互作用形成TSC蛋白复合物，该复合物在控制细胞生长中发挥作用。这个TSC蛋白复合物负调控哺乳动物雷帕霉素靶标1（mTORC1）信号通路，该信号通路是合成代谢细胞生长的主要调节因子。这个基因的突变与结节性硬化症和淋巴管平滑肌瘤病有关。[由RefSeq提供，2022年5月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TSC2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
