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中文小鼠
Optn - optineurin
Alias:
NRP
FIP2
HYPL
4930441O07Rik
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K63链接的多泛素修饰依赖的蛋白质结合活性。在细胞内蛋白质定位和I-kappaB激酶/NF-kappaB信号传导的负调控中起到上游或内部作用。位于细胞质核周区域。在包括消化系统、眼睛、生殖泌尿系统、肌肉骨骼系统和神经系统在内的几个结构中表达。此基因的人类同源物与骨鲍温病、肌萎缩侧索硬化症（多种）和高眼压（多种）有关。与人类OPTN（视紫红质）正交。[由基因组资源联盟，2022年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Optn Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
