Log In|Sign Up
中文人类
TP53BP1 - Tumor Protein P53 Binding Protein 1
Alias:
p202
53BP1
TDRD30
p53BP1
Favorite
这个基因编码一个在DNA双链断裂修复途径中发挥作用蛋白质，促进非同源末端连接(NHEJ)途径，并限制同源重组。这个蛋白质在DNA损伤反应中扮演多个角色，包括在DNA损伤后促进检查点信号传导，作为将DNA损伤响应蛋白质招募到受损染色质的支架，并通过限制双链断裂后的末端切除来促进NHEJ途径。这些角色在V(D)J重组、类切换重组和未受保护的端粒中也非常重要。可变剪接导致多个转录变异体，编码不同的异构体。[由RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TP53BP1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
