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中文人类
TNF - Tumor Necrosis Factor
Alias:
DIF
TNFA
TNFSF2
TNLG1F
TNF-alpha
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这个基因编码一种属于肿瘤坏死因子(TNF)超家族的多种功能炎症细胞因子。这种细胞因子主要由巨噬细胞分泌。它可以与TNFRSF1A/TNFR1和TNFRSF1B/TNFBR受体结合并以此发挥作用。这种细胞因子参与多种生物过程的调节，包括细胞增殖、分化、凋亡、脂质代谢和凝血。这种细胞因子与多种疾病有关，包括自身免疫性疾病、胰岛素抵抗、银屑病、类风湿关节炎、强直性脊柱炎、结核病、常染色体显性多囊肾病和癌症。这个基因的突变影响对脑疟疾、脓毒休克和阿尔茨海默病的易感性。在小鼠中的敲除研究也提示了这种细胞因子的神经保护作用。[RefSeq,2020年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TNF Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
