人类

TMPRSS2 - Transmembrane Serine Protease 2

Alias:
PRSS10
加入收藏
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个属于丝氨酸蛋白酶家族的蛋白质。编码的蛋白质包含一个类型II跨膜结构域,一个A类受体结构域,一个清道夫受体半胱氨酸丰富结构域和一个蛋白酶结构域。丝氨酸蛋白酶已知涉及许多生理和病理过程。这个基因被证明在前列腺癌细胞中受雄激素激素上调,而在雄激素依赖性前列腺癌组织中下调。这个蛋白质的蛋白酶结构域被认为在自切割后会被切割并分泌到细胞培养基中。这个蛋白质还通过蛋白水解切割和激活病毒包膜糖蛋白来促进病毒进入宿主细胞。发现使用这个蛋白质进行细胞进入的病毒包括流感病毒和人类冠状病毒HCoV-229E、MERS-CoV、SARS-CoV和SARS-CoV-2(COVID-19病毒)。已经发现这个基因的不同剪接转录变异体编码不同的异构体。[由RefSeq,2020年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3
14
43854 bp
53.86
21
--
16
26

TMPRSS2 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top