人类

TLR2 - Toll Like Receptor 2

Alias:
TIL4
CD282
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Toll样受体(TLR)家族的一员,在病原体识别和先天免疫激活中起基本作用。TLRs从果蝇到人类高度保守,并在结构和功能上相似。这种蛋白质是一种细胞表面蛋白质,可以与其他TLR家族成员形成异源二聚体,以识别来自已知为病原相关分子模式(PAMPs)的微生物的保守分子。PAMPs激活TLR导致信号通路上调,以调节宿主的炎症反应。这个基因也被认为能响应细菌脂蛋白促进细胞凋亡。这个基因与几种自身免疫疾病的病理学有关。选择性剪接导致多个转录变异体。[RefSeq,2016年1月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
16
3
26358 bp
89.84
47
2
14
29

TLR2 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
Al agent
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