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中文人类
TJP1 - Tight Junction Protein 1
Alias:
ZO-1
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这个基因编码膜相关鸟苷酸激酶(MAGUK)家族蛋白质的一员，并作为紧密连接适配蛋白，也调节粘附连接。紧密连接调节内皮细胞和上皮细胞之间离子和大分子运动。这个支架蛋白的多结构域结构，包括一个后突触密度95/disc-large/zona occludens(PDZ)结构域，一个Src同源(SH3)结构域，一个鸟苷酸激酶(GuK)结构域和独特的(U)基序，都有助于协调跨膜蛋白，胞质蛋白和F-肌动蛋白的结合，这些都是紧密连接功能所必需的。可变剪接导致多个转录变异体编码不同的异构体。[由RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TJP1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
