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中文人类
THRB - Thyroid Hormone Receptor Beta
Alias:
TRb
GRTH
PRTH
THR1
ERBA2
NR1A2
THRB1
THRB2
TRbeta
THRbeta
TRbeta1
C-ERBA-2
THRbeta1
Thrbeta2
C-ERBA-BETA
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这个基因编码的蛋白质是一种核激素三碘甲状腺原氨酸受体。它是甲状腺激素的几种受体之一，已经证明可以调节甲状腺激素的生物活性。小鼠的敲除研究表明，虽然这些受体具有一定的冗余性，但它们可能调节甲状腺激素的不同功能。这个基因的突变已被证明是全身甲状腺激素抵抗（GTHR）的原因，这是一种以甲状腺肿和循环甲状腺激素（T3-T4）高水平为特征的症状，而甲状腺刺激激素（TSH）正常或略高。已经观察到这个基因的几个可变剪接转录变异体，它们编码相同的蛋白质。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
THRB Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
