人类

THPO - Thrombopoietin

Alias:
ML
TPO
MGDF
MKCSF
MPLLG
THCYT1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
巨核细胞生成是导致血小板产生的细胞发育过程。这个基因编码的主要功能蛋白是一种体液生长因子,对于巨核细胞的增殖和成熟以及血小板生成是必要的。这个蛋白是MLP/C_MPL的配体,是髓系白血病病毒癌基因的产物。这个基因的突变是导致血小板增多症1的原因。替代启动子用法和差异剪接导致5'UTR和/或编码区不同的多种转录变异体。已经发现了主要开放阅读框(ORF)上游的多个AUG密码子,这些上游AUGs在不同程度上抑制了主要ORF的翻译。[由RefSeq,2014年2月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
11
6
7754 bp
37.82
106
8
8
13

THPO Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
Al agent
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