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中文人类
TGFBR2 - Transforming Growth Factor Beta Receptor 2
Alias:
AAT3
FAA3
LDS2
MFS2
RIIC
LDS1B
LDS2B
TAAD2
TBRII
TBR-ii
TGFR-2
tbetaR-II
TGFbeta-RII
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这个基因编码的蛋白质是一种跨膜蛋白质，具有蛋白激酶结构域，与TGF-beta受体1型形成异源二聚体复合物，并结合TGF-beta。这个受体/配体复合物磷酸化蛋白质，然后进入细胞核，调节与细胞增殖、细胞周期停滞、伤口愈合、免疫抑制和肿瘤发生相关的基因的转录。这个基因的突变与马凡综合症、Loeys-Deitz主动脉瘤综合症和多种肿瘤的发生有关。可变剪接转录本变异体已经表征，编码不同的异构体。[由RefSeq提供，2017年8月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TGFBR2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
