Unc13d - unc-13 homolog D

Predicted to enable small GTPase binding activity. Involved in platelet dense granule organization; positive regulation of substrate adhesion-dependent cell spreading; and vasculature development. Acts upstream of or within several processes, including defense response to other organism; germinal center formation; and granuloma formation. Predicted to be located in cytosol; lysosome; and secretory vesicle. Used to study familial hemophagocytic lymphohistiocytosis 3. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 3. Orthologous to human UNC13D (unc-13 homolog D). [provided by Alliance of Genome Resources, Apr 2022]