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中文人类
TDG - Thymine DNA Glycosylase
Alias:
hTDG
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这个基因编码的蛋白质属于TDG/mug DNA糖基化酶家族。胸腺嘧啶-DNA糖基化酶(TDG)通过水解DNA糖磷酸骨架与错配胸腺嘧啶之间的碳-氮键，从G/T错配中移除胸腺嘧啶部分。该酶的活性较低，还可以从C/T和T/T错配中移除胸腺嘧啶。TDG还可以从与鸟嘌呤的错配中移除尿嘧啶和5-溴尿嘧啶。这种酶在细胞防御中扮演着中心角色，以防止由5-甲基胞嘧啶和胞嘧啶的自发脱氨基引起的遗传突变。这个基因在染色体12的p臂上可能有一个假基因。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TDG Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
