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中文人类
BUB1 - BUB1 Mitotic Checkpoint Serine/threonine Kinase
Alias:
BUB1A
BUB1L
hBUB1
MCPH30
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这个基因编码一个丝氨酸/苏氨酸蛋白激酶，该激酶在有丝分裂中起着核心作用。编码的蛋白质部分通过磷酸化有丝分裂检查点复合物的成员和激活纺锤体检查点来发挥作用。这种蛋白质还起到抑制激活有丝分裂促进复合物/周期蛋白的作用。这种蛋白质也可能在DNA损伤反应中发挥作用。这种基因的突变已与非整倍体和几种癌症形式有关。交替剪接导致多种转录变体。[由RefSeq提供，2013年7月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
BUB1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
