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中文人类
TCF7 - Transcription Factor 7
Alias:
TCF-1
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这个基因编码一个T细胞因子/淋巴增强子结合因子家族的高移动性组(HMG)盒转录激活子成员。这个基因主要在T细胞中表达，并在自然杀手细胞和先天淋巴细胞发育中起到关键作用。编码的蛋白质与β-连环蛋白形成复合物，并通过Wnt/β-连环蛋白信号通路激活转录。这个基因敲除的小鼠是存活的且能繁殖，但显示T淋巴细胞分化受阻。可变剪接产生多个转录变异体。天然存在的缺乏N-末端β-连环蛋白相互作用结构的异构体可能作为Wnt信号的显性负调控子。[RefSeq,2016年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TCF7 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
