人类

MAP3K7 - Mitogen-activated Protein Kinase Kinase Kinase 7

Alias:
CSCF
FMD2
TAK1
MEKK7
TGF1a
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。这个激酶调节TGF beta和形态发生蛋白(BMP)诱导的信号转导,并控制各种细胞功能,包括转录调控和凋亡。在响应IL-1的情况下,这个蛋白质形成一个包括TRAF6、MAP3K7P1/TAB1和MAP3K7P2/TAB2的激酶复合物;这个复合物是核因子kappa B激活所必需的。这个激酶还可以激活MAPK8/JNK、MAP2K4/MKK4,因此在细胞对环境应力的反应中发挥作用。已经报道了一种编码不同异质体的四种可变剪接转录本。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5
17
73494 bp
67.20
208
3
16
56

MAP3K7 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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