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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TAF12 - TATA-box Binding Protein Associated Factor 12
Alias:
TAF2J
TAFII20
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
RNA聚合酶II的转录调控涉及到基质转录机器,这是一个蛋白质的集合。这些蛋白质与RNA聚合酶II结合,形成复合物,这些复合物受到与转录起始位点相邻的顺式调节元件上的转录激活蛋白的调节。一些调节蛋白直接与基质复合物相互作用,而其他调节蛋白可能作为桥梁蛋白,将转录激活蛋白与基质转录因子连接起来。这些相关因子中有一些是弱结合的,而其他一些则与TFIID复合物中的TBP紧密结合。其中后者是TAF蛋白。不同的TAF蛋白预计会介导各种基因启动子和RNA聚合酶的特定转录激活因子的功能。TAF12直接与TBP以及TAF2I相互作用。已经发现了两种转录变体,编码同一种蛋白质。[由RefSeq提供,2008年9月]
Related ID:
NCBI:6883
ENSEMBL:ENSG00000120656
HGNC:11545
UNIPROT:Q16514
OMIM:600773
Basic Information
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Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
6883
5
6
45420 bp
17.92
4
--
3
19
TAF12 Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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