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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TAF10 - TATA-box Binding Protein Associated Factor 10
Alias:
TAF2A
TAF2H
TAFII30
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
RNA聚合酶II的转录起始需要超过70种多肽的活动。协调这些活动的蛋白质是转录因子IID(TFIID),它结合核心启动子以正确定位聚合酶,作为转录复合物的其余部分组装的支架,并作为调节信号的通道。TFIID由TATA结合蛋白(TBP)和一组进化保守的蛋白质组成,称为TBP关联因子或TAFs。TAFs可能参与基础转录,作为协同激活物,在启动子识别中发挥作用,或者修改通用转录因子(GTFs)以促进复合物组装和转录起始。此基因编码与TFIID复合物子集相关联的TFIID的小亚单位之一。在人类和哺乳动物细胞中的研究表明,此亚单位对于雌激素受体的转录激活是必需的,对于细胞周期的进展是必需的,可能对于某些细胞分化程序也是必需的。[由RefSeq,2008年7月提供]
Related ID:
NCBI:6881
ENSEMBL:ENSG00000166337
HGNC:11543
UNIPROT:Q12962
OMIM:600475
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6881
1
5
5923 bp
21.71
324
--
2
19
TAF10 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
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No data available
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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