人类

TAGLN - Transgelin

Alias:
SM22
SMCC
TAGLN1
WS3-10
SM22-alpha
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一种形状变化和转化敏感的肌动蛋白结合蛋白,属于calponin家族。它广泛表达于血管和内脏平滑肌中,是平滑肌分化的早期标志物。编码的蛋白质被认为涉及钙离平滑肌收缩。它作为肿瘤抑制因子,其表达丢失是细胞转化和某些肿瘤发展的早期事件,与细胞塑性相一致。编码的蛋白质具有由N-末端calponin同源(CH)结构域和C-末端calponin样(CLIK)结构域组成的结构域架构。与其正链基因敲除的鼠类是存活且能生育的,但它们的血管平滑肌细胞中的肌动蛋白丝分布和细胞骨架组织发生变化。[由RefSeq,2017年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
5
8172 bp
22.61
21
--
9
11

TAGLN Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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