Tmem129 - transmembrane protein 129

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]