Jarid2 - jumonji and AT-rich interaction domain containing 2

Predicted to enable several functions, including histone demethylase activity; ubiquitin binding activity; and ubiquitin modification-dependent histone binding activity. Involved in negative regulation of cardiac muscle cell proliferation and negative regulation of cardiac muscle hypertrophy. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]