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中文人类
STAT6 - Signal Transducer And Activator Of Transcription 6
Alias:
STAT6B
STAT6C
D12S1644
IL-4-STAT
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这个基因编码的蛋白质是转录因子STAT家族的一员。响应细胞因子和生长因子，STAT家族成员被受体相关激酶磷酸化，然后形成同源或异源二聚体，转移到细胞核中作为转录激活子发挥作用。这个蛋白质在发挥IL4介导的生物应答中起核心作用。它被发现能诱导BCL2L1/BCL-X(L)的表达，后者负责IL4的抗凋亡活性。小鼠的敲除研究表明这个基因在辅助性T细胞2（Th2）细胞的分化、细胞表面标志物的表达和免疫球蛋白的类切换中发挥作用。可选的剪接导致多个转录变异体。[RefSeq,2010年5月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
STAT6 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
