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中文人类
STAT5B - Signal Transducer And Activator Of Transcription 5B
Alias:
STAT5
GHISID2
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这个基因编码的蛋白质是转录因子STAT家族的一员。响应细胞因子和生长因子，STAT家族成员被受体相关激酶磷酸化，然后形成同源或异源二聚体，转移到细胞核中作为转录激活因子。这个蛋白质介导各种细胞配体触发的信号传导，如IL2、IL4、CSF1和不同的生长激素。已经证明它参与多种生物过程，如TCR信号传导、凋亡、成年乳腺发育和肝脏基因表达的性别差异。这个基因在小部分急性早幼粒细胞白血病（APLL）中与视黄酸受体-α（RARA）基因融合。这个蛋白质介导的信号通路的不规则调节可能是APLL的原因。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
STAT5B Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
