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中文人类
STAT1 - Signal Transducer And Activator Of Transcription 1
Alias:
CANDF7
IMD31A
IMD31B
IMD31C
ISGF-3
STAT91
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这个基因编码的蛋白质是STAT蛋白质家族的一员。响应细胞因子和生长因子，STAT家族成员被受体相关激酶磷酸化，然后形成同源或异源二聚体，转移到细胞核中作为转录激活子发挥作用。这个基因编码的蛋白质可以由各种配体激活，包括干扰素-α、干扰素-γ、EGF、PDGF和IL6。这个蛋白质调节各种基因的表达，被认为对于响应不同的细胞刺激和病原体对细胞存活很重要。这个蛋白质在针对病毒、真菌和分支杆菌病原体的免疫应答中扮演重要角色。这个基因的突变与免疫缺陷31B、31A和31C有关。[由RefSeq，2020年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
STAT1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
