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中文人类
DENND2B - DENN Domain Containing 2B
Alias:
ST5
HTS1
p126
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这个基因通过其在裸鼠中抑制Hela细胞肿瘤形成能力而被鉴定。这个基因编码的蛋白质含有与Rab 3家族的小GTP结合蛋白相似的C端区域。这个蛋白质优先与c-Abl激酶的SH3结构域结合，并作为MAPK1/ERK2激酶的调节剂发挥作用，这可能有助于减少细胞中的肿瘤形成表型。这个基因的三个可变剪接转录变异体被鉴定，它们编码不同的异构体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
DENND2B Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
