Predicted to enable ubiquitin-protein transferase activity. Involved in angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleolus. Is expressed in hindgut; metanephros; pericardial component; testis; and thymus primordium. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Apr 2022]