Trim59 - tripartite motif-containing 59

Enables ubiquitin protein ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in endoplasmic reticulum. Is expressed in several structures, including Peyer's patch; genitourinary system; gut; nervous system; and skin. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Apr 2022]