Kdelr2 - KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

Predicted to enable KDEL sequence binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein retention in ER lumen; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Predicted to colocalize with COPI-coated vesicle membrane. Is expressed in limb; otic capsule; palatal shelf; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Apr 2022]