Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Acts upstream of or within several processes, including nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Apr 2022]