Acts upstream of or within cellular response to gamma radiation and nucleic acid metabolic process. Predicted to be located in nucleolus. Predicted to be part of transcription factor TFIID complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Is expressed in several structures, including 4-cell stage embryo; alimentary system; bone; ganglia; and telencephalon. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Apr 2022]