Cybb - cytochrome b-245 beta chain

Predicted to enable several functions, including flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of tumor necrosis factor production. Located in several cellular components, including neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Part of NADPH oxidase complex. Colocalizes with perinuclear endoplasmic reticulum. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain). [provided by Alliance of Genome Resources, Apr 2022]