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中文人类
SLC6A4 - Solute Carrier Family 6 Member 4
Alias:
HTT
5HTT
OCD1
SERT
5-HTT
SERT1
hSERT
5-HTTLPR
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这个基因编码一个整合膜蛋白，将神经递质5-羟色胺从突触空间运输到前神经元中。编码的蛋白质终止5-羟色胺的作用，并以依赖钠的方式将其循环利用。这种蛋白质是精神运动兴奋剂（如安非他命和可卡因）的靶点，并属于钠：神经递质转运体家族。该基因启动子中的重复长度多态性已被证明会影响5-羟色胺摄取的速度。文献中关于这种多态性在行为和抑郁方面可能发挥作用（如果有的话）的冲突结果。[RefSeq,2019年5月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SLC6A4 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
