Prkaa1 - protein kinase AMP-activated catalytic subunit alpha 1

Enables several functions, including AMP-activated protein kinase activity; ATP binding activity; and protein C-terminus binding activity. Involved in several processes, including cold acclimation; energy homeostasis; and fatty acid homeostasis. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Used to study type 2 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]