Cyp2j4 - cytochrome P450, family 2, subfamily j, polypeptide 4

Enables NADPH-hemoprotein reductase activity and arachidonic acid monooxygenase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and positive regulation of tumor necrosis factor production. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]