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中文人类
SHC1 - SHC Adaptor Protein 1
Alias:
SHC
SHCA
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这个基因编码三种主要异构体，它们的活性和亚细胞定位不同。虽然所有三种都是信号转导途径中的适配器蛋白，但最长的p66Shc可能涉及调节寿命和活性氧物种的影响。其他两种异构体p52Shc和p46Shc通过招募GRB2/SOS复合体将激活的受体酪氨酸激酶连接到Ras途径。p66Shc不参与Ras的激活。与其他两种异构体不同，p46Shc定位于线粒体基质。已经发现这个基因的几种转录变异体编码不同的异构体。[RefSeq，2011年2月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SHC1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
