Icos - inducible T-cell co-stimulator

Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]