Sirt2 - sirtuin 2

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]